The Power Of PRP
The human body has a remarkable capacity to heal itself. Regeneration of new tissue is accomplished by stem cells and is fostered by growth factors and hormones. Platelet-rich plasma (PRP) is an emerging treatment in many medical specialties: orthopedics, wound healing, surgery, aesthetic and sexual medicine.
How does Platelet Rich Plasma (PRP) work?
The Science of PRP
The body signals platelets and other components in our blood supply to migrate to the site of injury. Platelets are the injury’s first responders, and under normal conditions these platelets release various factors that initiate and subsequently stimulate repair, and promote new blood vessel development to accelerate tissue regeneration. A concentrated PRP that is activated leads to the release of many bioactive proteins responsible for regeneration by growth factors and by attracting mesenchymal stem cells to the treatment area
Inside the platelet are 2 types of granules, namely, alpha granules and dense bodies. Alpha granules contain the clotting and growth factors that are released in the healing process. Normally at the resting state, platelets require a trigger to activate and become a participant in wound healing and hemostasis.
Growth factors and other cytokines in platelets include the following: platelet-derived growth factor, transforming growth factor, fibroblast growth factor, insulin like growth factor 1, insulin like growth factor 2, vascular endothelial growth factor, epidermal growth factor, interleukin 8, keratinocyte growth factor, and connective tissue growth factor.
Are Platelet Rich Plasma (PRP) procedures FDA approved?
Platelet Rich Plasma (PRP) procedures are not approved or disapproved by FDA because PRP is not a drug. The FDA has approved the PRP harvesting kits that are used in the platelet collection process and they have been deemed safe. PRP has always shown to be safe and is effective at regeneration, healing and rejuvenation in many different medical specialties.
Advantages Of Using PRP
Advantages of using PRP include the following: tissue regeneration and rejuvenation, induction of cell differentiation, extracellular matrix formation, recruitment of other cells to the site, and an increase in collagen production, which can increase skin thickness and overall skin health. In addition, PRP is non-allergenic, is an autologous physiological product, eliminates donor transmissible infections, and is a biological glue for tissue adhesion, especially in skin flaps, bone grafts, and trauma.3
Preparation Of PRP
To prepare PRP, a small amount of blood is drawn from the patient’s arm. The blood is then placed in a centrifuge that spins at high speed and separates the platelets from the rest of the blood components. The typical baseline blood platelet count is approximately 200 000 per microliter; therapeutic PRP centrifuges concentrate the platelets by roughly 5-fold. However, broad variability exists in the production of PRP by various concentrating equipment and techniques. The platelets collected in PRP are activated by the addition of calcium chloride, which induces the release of these factors from alpha granules.
The entire process takes less than 15 minutes and increases the concentration of platelets and growth factors up to 600%, along with an inherent rise in human stem cell proliferation due to exposure to concentrated platelets up to 10 times above native levels. The concentrated PRP is then injected into and around the affected area, jump-starting and significantly strengthening the body’s natural healing signals. Injections of PRP heal the area over time, during 1 to 3 months. Because the patient’s blood is used, there is no risk of a transmissible infection and a low risk of allergic reaction.
Clinical Applications And Procedure
In humans, PRP has been investigated and used as a clinical tool for several types of medical treatments, including nerve injury, tendonitis, osteoarthritis, cardiac muscle injury, bone repair and regeneration, plastic surgery, and oral surgery. It has received attention in the popular media because of its use in treating sports injuries in professional athletes.
What is the Future of Platelet Rich Plasma (PRP)?
As people seek out alternative options to surgery for injuries and other conditions, therapies using PRP are becoming in demand. Patients and physicians alike are excited about PRP because PRP is a regenerative therapy. Treating patients with the healing power offered from their own body is revolutionary. Research is ongoing and the use of these treatments will continue as long as they prove to be effective.
Why is the same dose given to everybody?
My team and I insist on utilizing the best quality protocols and equipment necessary to achieve the best result. We do this by following the science and by collaborating with other creative and ethical medical experts in various fields.
The dosage of platelets can vary between patients because each persons starting platelet count can be a bit different. The PRP harvesting system used at Doctors Studio is validated and proven consistent in concentrating platelets, decreasing inflammatory causing WBC, increasing anti-inflammatory WBC, increasing growth factors and delivering a high quality PRP product.
Are there any considerations before having a PRP procedure?
Certain factors (eg, smoking and alcohol intake) diminish stem cell release. Avoiding these will increase the success of the PRP procedure.
The platelets work by causing an inflammatory reaction. If this inflammatory reaction is diminished, the clinical outcome is significantly compromised. Also, NSAIDS are found to inhibit degranulation. This means that there is a reduction in growth factor release from PRP. For this reason, the use of anti-inflammatory drugs after the procedure is not recommended since they may lower the effectiveness of the procedure. Ideally, you will restrict your use of NSAIDS for about 1 to 2 weeks before and after the procedures when possible.
Who should not have PRP Treatment?
Although PRP is a promising therapy for most patients, there are a few special considerations.
Patients with the following conditions may not be good PRP candidates:
- PREGNANCY OR LACTATION
- ACUTE AND CHRONIC INFECTIONS
- SKIN DISEASES (I.E. SLE, PORPHYRIA, ALLERGIES)
- CHEMOTHERAPY TREATMENTS
- SEVERE METABOLIC AND SYSTEMIC DISORDERS
- ABNORMAL PLATELET FUNCTION (BLOOD DISORDERS, I.E. HAEMODYNAMIC INSTABILITY, HYPOFIBRINOGENEMIA, CRITICAL THROMBOCYTOPENIA)
- CHRONIC LIVER DISEASE
- ANTI-COAGULATION THERAPY (COUMADIN, WARFARIN, PLAVIX, ASPIRIN, LOVENOX)
- UNDERLYING SEPSIS
- SYSTEMIC USE OF CORTICOSTEROIDS WITHIN TWO WEEKS OF THE PROCEDURE.
Adverse Effects Of PRP Treatment
Serious adverse effects are rare but can occur; allergic reaction (a rare occurrence), and blood clot (because PRP therapy uses a needle, a vein could be damaged).
Common post injection effects are bruising, and mild pain in the injected area.
Technique Is Key
As with all therapies, adequate training and experience are paramount. The beauty of the PRP technology is its safety but in order to have the most effective outcome, technique, knowledge and experience are the key differences in outcomes. So chose a provider that not only uses equipment to create the best quality PRP but also one that knows how to use it.
Can I have a consultation without having the procedure?
We encourage you to schedule a brief consultation before scheduling the procedure. In this consultation (which can be done over the phone) you will have an opportunity to have all of your questions answered. You will also be provided important information to help you have the best possible experience and results.
Can I have a consultation and the procedure in the same day?
You may have services on the same day as a consultation as long as you make your desire for service known at the time of scheduling.
What Is The O-Shot Clinical Protocol?
For several weeks after the O-Shot procedure, you are asked to use the APEX M pelvic bowl exerciser device to stimulate and strengthen the pelvic floor muscles. Please use the device daily for a minimum of 10 minutes for 2 weeks. The more you use the device the better. You may continue daily or weekly use indefinitely for continued benefit.
Does The O-Shot Treat Urinary Incontinence?
Many women report significant improvement of stress and urge incontinence. There are many reports of total resolution of the problem. Strengthening the pelvic floor musculature in conjunction with PRP can significantly impact urinary incontinence. StudioPRP Providers recommend using the APEX medical device in combination with PRP for the best outcome.
Does The O-Shot Procedure Hurt?
Most women are quite comfortable during the procedure. The discomfort is often described as a mild pinch or mild sting, lasting only a few minutes. The numbing feeling may last 30-60 minutes after the procedure.
Do I Need To Come Back For A Follow Up Visit After The Procedure?
Generally a brief phone conversation or office visit (15 minutes) at 4 weeks is recommended. (No charge). A plan for further care will be considered at that time.
Will I need a second O-Shot?
Some women choose to have a second O-Shot for various reasons. You may have a 2nd O-Shot after 4 weeks should you desire.
How Many O-Shots May I Have?
There is no limit to the number of O-Shots a woman can have safely. Evaluation by a physician skilled in the use of PRP is necessary to determine potential risk and benefit.
Is The O-Shot Covered By Insurance?
Currently this procedure is not covered by insurance including Medicare.
Are There Any Studies Or Research On The O-Shot Procedure?
Can I Have The O-Shot Done If I Am Pregnant?
Women who are pregnant or lactating should not have the O-Shot procedure.
If you are not sure – a pregnancy test will need to be done prior to the procedure.
You will be asked to sign a document to verify that you are not pregnant or lactating at time of the procedure.
Can I Have The O-Shot If I Am Menstruating?
Yes, you can have the procedure done during menstruation. Anytime of the month in a woman’s cycle is acceptable.
Are There Any Guarantees With The O-Shot Procedure?
This is an elective procedure and there are no guarantees that you will achieve the desired results. It may take more than one procedure to reach your desired goals.
Are There Any Side Effects Or Downtime With The O-Shot?
There are typically no side effects or downtime. There may be a few drops of blood from the injection site. You can return to work, exercise and any other activity the same day (including sexual activity).
P- Shot FAQs
What Should I Expect During My Appointment?
Dr. Roy will review your medical history. You will have an opportunity to ask questions should you have any. A topical numbing cream is applied to the injection area (s). Your blood is then drawn and prepared. Once your PRP is ready, the doctor will inject into the desired area.
You will then be instructed on how to use the VED pump for the best regenerative results. The entire visit will last approximately 45 minutes.
Are There Any Side Effects Or Down Time?
There are typically no side effects or downtime. A small superficial bruise may develop at the injection site. You can return to work, exercise and any other activity the same day (including sexual activity).
What Is The P-Shot Post Procedure Protocol?
After the Priapus Shot procedure you are instructed to use a vacuum erection device (VED) to stretch the tissues of the penis for 10 minutes twice daily a minimum of 6 weeks to get the maximum benefit. You may pump for 10 minutes in same session with 5-minute break between. It is ok to continue pumping past 6 weeks. It is also OK to pump up to 30 minutes twice daily, allowing 60 minutes between sessions. The mechanical stretching of the tissue acts as a catalyst to continue the regenerative process. If increased girth and length are desired, you will likely need to pump frequently until your goal is reached (months to years). Subsequent P-Shots may help to facilitate this process.
Do I Need To Come Back For A Follow Up Visit After The P-Shot Procedure?
Generally a brief phone conversation or office visit (15 minutes) at 4 weeks is recommended after your procedure. (No charge). A plan for further care will be considered at that time if necessary.
Will I Need A 2nd P-Shot?
Some men choose to have a 2nd P-Shot for various reasons. You may have a 2nd Priapus Shot after 4 weeks should you desire.
How Many Priapus Shots Can I Have?
There is no known limit to the number of P-Shots a man can have safely.
Is There Any Research Or Current Studies Involving PRP And P-Shot?
There are published studies showing effectiveness in animals and small groups of men for. There are current studies underway. The results of these studies will be reported and published as soon as possible. Dr. Roy and the Studio team are involved in clinical research as a leader in PRP treatments for men and women.
Is The P-Shot Covered By Insurance?
Currently this procedure is not covered by insurance including Medicare.
Will The P-Shot Help With Erectile Dysfunction (ED)?
Erectile Dysfunction is often due to cardiovascular disease, diabetes, anxiety and medication side effects. Having satisfying sexual function depends upon blood flow, nervous system function, and the overall quality of tissue, health and hormone levels.
Many men with ED seek treatment and are given the option from medications both oral and injectable to surgical implants.
The P-Shot is an excellent treatment for ED and for men interested in better sexual function and the prevention and preservation of sexual function. PRP can be used safely in conjunction to other treatments you may be using for ED.
It may be necessary for more than one Priapus Shot to achieve the functional goals. There is usually additional benefit with subsequent Priapus Shot procedures spaced at a minimum of 4 weeks apart.
For preventative care or to maintain good erectile function and sensitivity it is recommended that you consider an annual Priapus Shot.
What Can I Expect If I Have Tried Other Medications For ED?
The P-Shot procedure can rejuvenate the penile tissue so that other treatments work more effectively. The results are variable and there has not been enough data collected to provide success rate statistics. Most men report benefit but the specifics are variable. It sometime takes more than one P-Shot to reach desired goals.
Are There Any Guarantees With The P-Shot Procedure?
This is an elective procedure and there are no guarantees that you will achieve the desired results. If you are seeking enhancement as your main goal, you may need a 2nd or 3rd shot along with the pumping protocol to achieve your goals or learn more about Studio Girth
Does This Procedure Help With Peyronie’s Disease?
Men typically do see improvement of Peyronie’s Disease when treated with PRP. Pain, discomfort and curvature are reported to decrease in most men. It may take several PRP injection series in order to reach your goal. There have been no reports of worsening Peyronie’s after this procedure. Most frequently, PRP is combined with Amniotic Product and Shock Wave Therapy for the fastest and most effective treatment for Peyronie’s Disease.